Developing biotherapeutics,
biobetters, and innovative products

know us

What we do?

We develop an innovative human erythropoietin-based neurotherapeutic to meet the needs of millions of people around the world who suffer from central nervous systems conditions like Parkinson´s disease, Alzheimer´s disease, multiple sclerosis, stroke, among others; for which, nowadays there is no effective treatment.

How we do it?

Human erythropoietin (hEPO) is a widely used biotherapeutic for anemia treatment because it stimulates red blood cells production.  Besides, hEPO has neuroprotective and neuroplastic activity. Nevertheless, when it is used as a neuropharmaceutical in patients who do not suffer from anemia, it causes erythropoietic activity-associated side effects. Thus, from BioSynaptica, we have developed hEPO-based neurotherapeutic candidates through an innovative idea, to block its undesired effect but preserving its neurotherapeutic potentiality.

Development of new hEPO variants through glycoengineering

In vitro and in vivo confirmation of their blocked erythropoietic activity

Confirmation of their potentiality to promote neuroplastic/neuroprotective action on neuron-derived primary cultures

Validation for their long-lasting circulation in blood

National phase patent request (after positive evaluation of patentability by PCT) in Europe, EEUU, and twelve other countries which represent the most promising markets

 

Evaluation of their in vivo capacity to cross the blood-brain barrier and their neuroplasticity (proof-of-concept in wild type animals)

To develop and to scale up the production process of the hEPO-variants

To confirm theirneuroprotective/neuroplastic actions in animal models of humanneurological disorders

To begin pre-clinical trials

WHO WE ARE?


Milagros Bürgi, PhD

Co-Founder
BioSynaptica SA


Marcos Oggero-Eberhardt, PhD

Co-Founder
BioSynaptica SA


Ricardo Kratje, PhD

Co-Founder
BioSynaptica SA


Matías Depetris, PhD

Director & Co-Founder
BioSynaptica SA

¿Quiénes Somos?


Dra. Milagros Bürgi

Socia co-fundadora
BioSynaptica S.A.


Dr. Ricardo Kratje

Socio co-fundador
BioSynaptica S.A.


Dr. Marcos Oggero-Eberhardt

Socio co-fundador
BioSynaptica S.A.


Dr. Matías Depetris

Socio co-fundador
BioSynaptica S.A.

Contact

admin@biosynaptica.com

+54 9 342 4625309

@biosynaptica

 @biosynaptica

Santa Fe, Argentina.

Contact us

Contact Us

Contacto


admin@biosynaptica.com


+54 9 342 4625309


@biosynaptica


@biosynaptica

Santa Fe, Argentina.

Contact Us